Influences of cholecystokinin octapeptide on phosphoinositide turnover in neonatal-rat brain cells
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چکیده
منابع مشابه
Influences of cholecystokinin octapeptide on phosphoinositide turnover in neonatal-rat brain cells.
Cholecystokinin octapeptide (CCK-8) has been shown to be coupled to phosphoinositide turnover in pancreatic acini as well as in a kind of neuroblastoma cell and a human embryonic cell line. Little is known, however, about its link with phosphatidylinositol breakdown in the brain. The brains (minus cerebella) from 1-2-day-old neonatal rats were enzymically dissociated into single cells. The inta...
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We have investigated the pathway and the mechanism by which cholecystokinin octapeptide (CCK-8), given systemically, may influence the discharge of brain stem neurons that have an input from the stomach. Extracellular recordings were made from neurons in the nucleus of the solitary tract (NTS), where vagal afferents terminate, and from neighboring regions of the dorsal medial medulla. Gastric d...
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The relationship between the density of the muscarinic receptor in developing rat cerebral cortex and its coupling to phosphoinositide turnover is examined. Tissue slices from rats of various ages were incubated with myo-[2-3H]inositol, and the effect of carbamoylcholine on the release of total inositol phosphates was determined. Binding of [3H]quinuclidinyl benzilate was determined in the same...
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Two components--one resembling intact cholecystokinin in size and charge and immunologic specificity, and the other resembling the COOH-terminal octapeptide of cholecystokinin--have been found in extracts of the pig cerebral cortex. The relative concentrations of the two peptides in the extracts were dependent on the extractant, boiling 0.1 M HCl being more effective than boiling water for the ...
متن کاملEffect of cholecystokinin octapeptide on food intake in pigs.
Considerable interest has been aroused by the suggestion that the gut hormone cholecystokinin (CCK) is released during feeding and then acts as a satiety signal (Gibbs et al. 1973). Many studies, in species ranging from the mouse to man, have shown that peripheral administration of CCK, or its octapeptide, will reduce food intake. However, inhibition of feeding could be produced via a satiety s...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1992
ISSN: 0264-6021,1470-8728
DOI: 10.1042/bj2850847